RESUMO
Background: Signet-ring cell colorectal carcinoma (SRCC) is an extremely aggressive yet uncommon histologic subtype of colorectal cancer (CRC) with an unknown etiology. There is a stark difference in the prevalence of signet cancers between Western countries and the Indian subcontinent; however, India itself is a vast and diverse country with variable cancer incidence. Objective: To study the spatial epidemiology of SRCC in India for identifying regions with high prevalence. Methods: This retrospective study included all patients diagnosed with colorectal adenocarcinoma at Tata Memorial Hospital, the largest colorectal cancer referral unit in India, between January 2020 and December 2022. Geocoding based on the location of the residence was done to map the incidences. Comparisons were performed between the proportion of signet cell and non-signet colorectal cancers. Results: A total of 4100 patients with colon or rectal adenocarcinomas were included, of which signet cell histology was found in 624 (15%) patients. SRCC accounted for the highest proportions of CRCs in the Central (19%) and Northern (19%) regions, and the lowest in the North-Eastern (10%) and Western (12%) regions of India (P < 0.001), with non-overlapping confidence intervals. Compared with patients with non-signet CRCs, those with SRCC more commonly had colon cancers (22% vs. 17%; P = 0.003) and belonged to a lower socioeconomic background (67% vs. 59%; P < 0.001). Conclusions: This study found that SRCCs accounted for a significant proportion of CRC cases in India, but there was no substantial disparity in distribution across regions.
RESUMO
Acne vulgaris is a universal multifactorial human skin condition of the pilosebaceous units. Although acne majorly prevails in teenagers, it is neither restricted to age group nor gender. Multifarious causative factors like Propionibacterium acnes, dysregulated sebum secretion, and androgens play an integral role in the manifestation of acne. Though abundant new chemical entities are convenient for acne therapy, none can treat this condition without compromising patient compliance. Furthermore, accessible treatment prevents the ailment and alleviates signs and symptoms with no absolute cure. So presently, despite the variety of topical formulations, the current market demands an ideal remedy to fulfill the unmet need for acne management. Extensive research has proved the upper hand of novel carrier systems over conventional formulations by substantially improving efficacy and eliminating unpleasant side effects. Lipid-based vesicular and particulate systems are promising prospects due to their closeness to the intrinsic structure of the skin, which offer delivery of the actives in a more desirable approach. This review underlines the practicability and superiority of liposomes, niosomes, transfersomes, ethosomes, cubosomes, solid lipid nanoparticles, and nanostructured lipid carriers over conventional therapies for acne. The review also highlights acne product market survey and available conventional as well as novel formulations portraying their scope in the market. In a nutshell, lipid-based vesicular and particulate systems prevail as a propitious modality for treating acne vulgaris as they conduce better penetrability, localized action, and reduce adverse effects. These systems have the ability to open a window of opportunities for effective acne alleviation.
